Background: Hepatitis C virus [HCV] infection is a major health problem. Chronic HCV is the main cause of liver cirrhosis and liver cancer in Egypt and one of the top five leading causes of death.
Toll-like receptors [TLRs] are a family of innate immune receptors known as pattern recognition receptors. There is an associations between single nucleotide polymorphisms [SNP] in TLRs and increased risk of infection Objective: The aim of this study was to determine the association between TLR7 [rs179008 gene] polymorphism and Chronic hepatitis C infection with and without Hepatocellular Carcinoma [HCC]
Methodology: Fifty nine patients suffering from HCV and HCC and twenty one sex and age matched healthy controls were included in the study. SNP of TLR 7 [rs179008 gene] was detected by genotyping assay using Real Time PCR Results: We found no significant difference between males HCV patients and control group. However, significant differences were found for the distribution of TLR7 [rs179009] in females [Chi  =5.98, p=0.01] with HCC in comparison to controls
Conclusion: The site of TLR7 [rs179009] may be a factor for susceptibility of chronic HCV in the female population to HCC. The [AT] genotype is significantly higher in female HCC group compared to control group. These patients could then be subjected to a more careful or earlier routine screening for HCC
Yara S. Elsedawy ,Yara S. Elsedawy ,Mona A. Khattab ,Soha A. El Hady ,Abeer A. El Sayed ,Ashraf M. Albreedy ,Zeinab M. Hefny ,
Single nucleotide polymorphisms of toll-like receptor 7 in hepatitis c virus infection and hepatocellular carcinoma patients,
Egypt. J. Med. Microbiol. 2016;
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