Platelet and factor VIII [F-VIII] storage and phagocytic functions of the spleen were studied in 15 patients with beta-thalassemia major who were not splenectomized and in 7 patients with Hb-S-beta-thalassemia.
Eight splenectomized patients, 4 patients with beta-thalassemia major, and 11 healthy children served as controls. F-VIII elevation following adrenalin was not found to be a sensitive index in the evaluation of [functional hyposplenia] . No fuctional derangement of the organ was shown in the patients with beta-thalassemia major. However, one of the tests showed that at least 30% of the patients had functional hyposplenism. Higher platelet counts were observed in the patients without palpable spleen, and the independence of the splenic functions were shown