Objectives : Chronic diarrhea is a major problem worldwide with high morbidity and mortality. Study design : it is a retrospective study. The medical records of the patients with chronic diarrhea who were subjected to endoscopic evaluation were revised. The study was conducted on patients who attended the pediatric Gastroenterology and Endoscopy unit of Alex and ria Children’s University Hospital along two years from January 2012 to December 2013. Methodology : The medical records were revised for : history, clinical examination, laboratory investigation and endoscopic findings. Results : forty patients were included in this study. The age range of the patients was from three months to eleven years. Patients from rural areas more than from urban regions, sixty five percent of the patients were males. Mucoid diarrhea was the most common type of diarrhea. Failure to thrive was evident in abetalipoproteinemiaandinflammatory bowel disease. Fecal calprotectin above 150mg/kg is highly specific and sensitive f or inflammatory bowel disease. Esinophilic enteroclolitis was the most common disease [57.5%] followed by celiac disease [15%] then ulcerative colitis [12.5%] . Conclusion : Management of patients with chronic diarrhea should be initiated and followed in a specialized Pediatric GIT unit since it requires experience and close clinical endoscopic and pathological assessment.