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  4. Subsequent impaired fertility [with or without sperm worsening]in men who had fathered children after a left varicocelectomy: a novel population?

Subsequent impaired fertility [with or without sperm worsening]in men who had fathered children after a left varicocelectomy: a novel population?

Authors

Cavallini Giorgio
Beretta, Giovanni
Biagiotti, Giulio
Mallus, Roberto
Maretti, Carlo
Pescatori, Edoardo
Paulis, Gianni
Gynepro-Medical Group ; , Department of Andrology ;

Urol. Ann. 2015; 7 (1): 79-85
Urology Annals
Journal Country: Saudi Arabia
P-ISSN: 0974-7796
E-ISSN: 0974-7834
Type of Publication: Journal Article
Category: Humans, Male,
Type of Research: Clinical
Keywords: Varicocele / Surgery
Broad Subjects: Health Systems, Fertility ,Infertility, Male ,Spermatozoa ,Retrospective Studies
Citation: Giorgio Cavallini ,Giovanni Beretta ,Giulio Biagiotti ,Roberto Mallus ,Carlo Maretti ,Edoardo Pescatori ,Gianni Paulis , Subsequent impaired fertility [with or without sperm worsening]in men who had fathered children after a left varicocelectomy: a novel population?, Urol. Ann. 2015; 7 (1): 79-85

Abstract English

The objective of this paper was to assess whether the beneficial effects of a varicocelectomy on fertility are transitory or definitive after a first fathering. This was a retrospective study which involved seven andrological centers. The files of 2223 patients who underwent subinguinal ligation of a high grade left varicocele for [oligo] +/- [astheno] +/- [terato] -spermia and infertility between January 1 [st] , 2002 and January 1 [st] 2013 were reviewed. Inclusion criteria for the patients were the following: Sperm count improvement and fathering a child after an uneventful left varicocelectomy; 745 patients were considered. Patients who had undergone three assessments for [in-] fertility: Before surgery, before the first fathering and after the first fathering were included in the study. Each assessment included: Clinical history, physical examination, two sperm analyses, bilateral scrotal Duplex scans, blood hormonal levels [follicle stimulating hormone [FSH] , luteinising hormone [LH] , testosterone [T] and prolactin [PRL] . Forty patients were finally studied; they all had an improved sperm count and had fathered once after surgery. Fifteen had fathered twice and still had their sperm count increased after the second fathering. Twenty-five patients could not father twice; 13 patients had their sperm count decreased after the first fathering and 12 did not. A decrease in testicular volume and an increase in FSH paralleled the worsening of sperm concentration, motility and morphology after fathering. No other differences could be observed between the groups. Our data indicated that the beneficial effects of a varicocelectomy might be transitory in some cases

Full Text English

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