COVID-19 | Discover the latest peer-reviewed research articles from the Eastern Mediterranean Region
COVID-19 | Discover the latest peer-reviewed research articles from the Eastern Mediterranean Region
COVID-19 | Discover the latest publications published by WHO Regional Office for the Eastern Mediterranean
COVID-19 | Discover the latest publications published by WHO Regional Office for the Eastern Mediterranean

Virtual Health Sciences Library

  • Home
  • Search
  • Knowledge Base
  • Get a journal indexed in the Index Medicus
  • MyVHSL
  1. Home
  2. IMEMR
  3. Search Result
  4. Synthesis and anticonvulsant activity evaluation of 3-alkoxy-4-[4- [hexyloxy/heptyloxy]phenyl]-4H-1, 2, 4 -triazole

Synthesis and anticonvulsant activity evaluation of 3-alkoxy-4-[4- [hexyloxy/heptyloxy]phenyl]-4H-1, 2, 4 -triazole

Authors

Fang Ying Quan
Sun, Chun Ling
Liu, Da Chuan
Wang, Shi Ben
Quan, Zhe San
Yanbian University ; , Chongqing Three Gorges Medical College ; , Department of Pharmacy ;

Iran. J. Pharm. Res. 2015; 14 (1): 77-87
IJPR-Iranian Journal of Pharmaceutical Research
Journal Country: Islamic Republic of Iran
P-ISSN: 1735-0328
E-ISSN: 1726-6890
Type of Publication: Journal Article
Category: Animals, Laboratory,
Type of Research: Experimental Studies
Keywords: Triazoles
Broad Subjects: Health Systems, Anticonvulsants ,Electroshock ,Mice
Citation: Ying Quan Fang ,Chun Ling Sun ,Da Chuan Liu ,Shi Ben Wang ,Zhe San Quan , Synthesis and anticonvulsant activity evaluation of 3-alkoxy-4-[4- [hexyloxy/heptyloxy]phenyl]-4H-1, 2, 4 -triazole, Iran. J. Pharm. Res. 2015; 14 (1): 77-87

Abstract English

A series of 3-alkoxy-4- [4- [hexyloxy/heptyloxy] phenyl] -4H-1, 2, 4-triazole was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock [MES] test and rotarod tests with intraperitoneally injected mice. Among the synthesized compounds, compound 3-heptyloxy-4- [4- [hexyloxy] phenyl] -4H-1, 2, 4-triazole [5f] was the most active one and also had the lowest toxicity. In the anti-MES potency test, it showed median effective dose [ED [50] of 37.3 mg/Kg, median toxicity dose [TD [50] of 422.5 mg/Kg, and the protective index [PI] of 11.3 which is much greater than the reference drug carbamazepine with PI value of 6.4. As well as demonstrating the anti-MES efficacy of compound 5f, its potency against seizures induced by pentylenetetrazole, 3-mercaptopropionic acid, and bicuculline were also established, with the results suggesting that GABA-mediated mechanisms might be involved in its anticonvulsant activity, such as enhancing of GABAergic neurotransmission or activity, activate GAD or inhibit GABA-T, and GABA [A] -mediated mechanisms

Full Text English
1 Downloads

Subscribe to VHSL Newsletters

© 2020 WHO – EMRO