Synthesis and antiplatelet aggregation activity evaluation of some 2-aminopyrimidine and 2-substituted-4, 6-diaminopyrimidine derivatives 
Iran. J. Pharm. Res. 2015;
14
(2):
417-424 Esfahanizadeh Marjan ; Mohebbi, Shohreh; Bozorg, Behnam Dasht; Amidi, Salimeh; Gudarzi, Ali; Ayatollahi, Seyed Abdolmajid; Kobarfard, Farzad
Shahid Beheshti University of Medical Sciences ; , School of Pharmacy ; Central Research Laboratories, Department of Medicinal Chemistry ;
IJPR-Iranian Journal of Pharmaceutical Research Journal Country: Islamic Republic of Iran
ISSN: 1735-0328 ISSN E: 1726-6890 Type of Publication: Journal Article Type of Research: Experimental Studies
Keywords: Health Systems,Essential Medicines, Pyrimidines
Subjects: Platelet Aggregation Inhibitors , Chemical Synthesis
A series of novel 2-aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic
acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, I [b] , I [B] and II [16] exhibited the highest antiplatelet aggregation activity [36.75, 72.4, 62.5 and 80 microM] . None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid.2- aminopyrimidines were more active than 4, 6- diaminopyrimidines in this respect
Citation: Marjan Esfahanizadeh ,Shohreh Mohebbi ,Behnam Dasht Bozorg ,Salimeh Amidi ,Ali Gudarzi ,Seyed Abdolmajid Ayatollahi ,Farzad Kobarfard , Synthesis and antiplatelet aggregation activity evaluation of some 2-aminopyrimidine and 2-substituted-4, 6-diaminopyrimidine derivatives, Iran. J. Pharm. Res. 2015; 14 (2): 417-424
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