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  4. Synthesis and antiplatelet aggregation activity evaluation of some 2-aminopyrimidine and 2-substituted-4, 6-diaminopyrimidine derivatives

Synthesis and antiplatelet aggregation activity evaluation of some 2-aminopyrimidine and 2-substituted-4, 6-diaminopyrimidine derivatives

Authors

Esfahanizadeh Marjan
Mohebbi, Shohreh
Bozorg, Behnam Dasht
Amidi, Salimeh
Gudarzi, Ali
Ayatollahi, Seyed Abdolmajid
Kobarfard, Farzad
Shahid Beheshti University of Medical Sciences ; , School of Pharmacy ; Central Research Laboratories, Department of Medicinal Chemistry ;

Iran. J. Pharm. Res. 2015; 14 (2): 417-424
IJPR-Iranian Journal of Pharmaceutical Research
Journal Country: Islamic Republic of Iran
P-ISSN: 1735-0328
E-ISSN: 1726-6890
Type of Publication: Journal Article
Type of Research: Experimental Studies
Keywords: Platelet Aggregation Inhibitors / Chemical Synthesis
Broad Subjects: Health Systems, Pyrimidines
Citation: Marjan Esfahanizadeh ,Shohreh Mohebbi ,Behnam Dasht Bozorg ,Salimeh Amidi ,Ali Gudarzi ,Seyed Abdolmajid Ayatollahi ,Farzad Kobarfard , Synthesis and antiplatelet aggregation activity evaluation of some 2-aminopyrimidine and 2-substituted-4, 6-diaminopyrimidine derivatives, Iran. J. Pharm. Res. 2015; 14 (2): 417-424

Abstract English

A series of novel 2-aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, I [b] , I [B] and II [16] exhibited the highest antiplatelet aggregation activity [36.75, 72.4, 62.5 and 80 microM] . None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid.2- aminopyrimidines were more active than 4, 6- diaminopyrimidines in this respect

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