Synthesis and antiplatelet aggregation activity evaluation of some 2-aminopyrimidine and 2-substituted-4, 6-diaminopyrimidine derivatives
Esfahanizadeh Marjan
Mohebbi, Shohreh
Bozorg, Behnam Dasht
Amidi, Salimeh
Gudarzi, Ali
Ayatollahi, Seyed Abdolmajid
Kobarfard, Farzad
Mohebbi, Shohreh
Bozorg, Behnam Dasht
Amidi, Salimeh
Gudarzi, Ali
Ayatollahi, Seyed Abdolmajid
Kobarfard, Farzad
Shahid Beheshti University of Medical Sciences ; , School of Pharmacy ; Central Research Laboratories, Department of Medicinal Chemistry ;
IJPR-Iranian Journal of Pharmaceutical Research Journal Country: Islamic Republic of Iran
P-ISSN: 1735-0328 E-ISSN: 1726-6890 Type of Publication: Journal Article Type of Research: Experimental Studies
Keywords: Platelet Aggregation Inhibitors / Chemical Synthesis
Broad Subjects: Health Systems, Pyrimidines
Citation: Marjan Esfahanizadeh ,Shohreh Mohebbi ,Behnam Dasht Bozorg ,Salimeh Amidi ,Ali Gudarzi ,Seyed Abdolmajid Ayatollahi ,Farzad Kobarfard , Synthesis and antiplatelet aggregation activity evaluation of some 2-aminopyrimidine and 2-substituted-4, 6-diaminopyrimidine derivatives, Iran. J. Pharm. Res. 2015; 14 (2): 417-424
A series of novel 2-aminopyrimidine and 2-Substituted-4, 6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, I [b] , I [B] and II [16] exhibited the highest antiplatelet aggregation activity [36.75, 72.4, 62.5 and 80 microM] . None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid.2- aminopyrimidines were more active than 4, 6- diaminopyrimidines in this respect
