Synthesis and biological evaluation of metronidazole derivatives as anti-giardia agents
Shahriari Bahador
Shiraz University of Medical Sciences ; , Basic Sciences in Infectious Diseases Research Center ; ,
TIPS-Trends in Pharmaceutical Sciences Journal Country: Islamic Republic of Iran
P-ISSN: 2423-3722 E-ISSN: 2423-5652
Indexing Status : In Process
Citation: Bahador Shahriari , Synthesis and biological evaluation of metronidazole derivatives as anti-giardia agents, Trends Pharm. Sci. 2015; 1 (2): 105-110
Nitroimidazole derivatives such as Metronidazole [MTZ] have been used as anti- protozoa and anti-anaerobic bacteria. In this study several compounds of MTZ derivatives were synthesized and evaluated against Giardia lamblia cyst. Firs MTZ were reacted with several alkyl halide to obtain O-alkyl MTZ derivatives, then products were purified and their chemical structures were confirmed by elemental and spectral analysis [1HNMR and Mass] . In order to biological evaluation all compounds were investigated against 25 Giardia samples isolated from giarfdiasis patients. Results showed compound 2a had the most activity on cyst of Giardia in comparison with MTZ
