Synthesis and biological evaluation of metronidazole derivatives as anti-giardia agents 
Trends Pharm. Sci. 2015;
1
(2):
105-110 Shahriari Bahador ; Rezaei, Zahra; Khabnadideh, Soghra; Sadeghpour, Hossein; Hatam, Gholam Reza; Asgari, Qasem; Kiani, Amin; Firoozi, Fardad
Shiraz University of Medical Sciences ; , Basic Sciences in Infectious Diseases Research Center ; ,
TIPS-Trends in Pharmaceutical Sciences Journal Country: Islamic Republic of Iran
ISSN: 2423-3722 ISSN E: 2423-5652
Indexing Status : In Process
Nitroimidazole derivatives such as Metronidazole [MTZ] have been used as anti- protozoa and anti-anaerobic bacteria. In this study several compounds of MTZ derivatives were synthesized and evaluated
against Giardia lamblia cyst. Firs MTZ were reacted with several alkyl halide to obtain O-alkyl MTZ derivatives, then products were purified and their chemical structures were confirmed by elemental and spectral analysis [1HNMR and Mass] . In order to biological evaluation all compounds were investigated against 25 Giardia samples isolated from giarfdiasis patients. Results showed compound 2a had the most activity on cyst of Giardia in comparison with MTZ
Citation: Bahador Shahriari ,Zahra Rezaei ,Soghra Khabnadideh ,Hossein Sadeghpour ,Gholam Reza Hatam ,Qasem Asgari ,Amin Kiani ,Fardad Firoozi , Synthesis and biological evaluation of metronidazole derivatives as anti-giardia agents, Trends Pharm. Sci. 2015; 1 (2): 105-110
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