Some new 6-[6-[1, 2, 3, 4-tetrahydronaphthyl] 3-cyano-4-aryl-2 [1H] pyridinthiones [IIa-h] were synthesized by the reaction of 6-acetyltetralin with alpha-, beta-unsaturated nitrites [Ia-h] .
Some of the new pyridinthiones showed considerable inhibitory effect on aspartate and alanine aminotransferase [AST and ALT] in bilharzia snails Biomphalaria alexandrina, while they increased the activity of lactate dehydrogenase in these snails
M. M. Kamel ,
Synthesis and the effect of some new 2 [1H]pyridinthiones on biomphalaria alexandrina snails enzymes,
Egypt. J. Pharm. Sci. 1994;
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