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  4. The metabolic syndrome and inflammation: role of insulin resistance and increased adiposity

The metabolic syndrome and inflammation: role of insulin resistance and increased adiposity

Authors

Farooq Wajiha
Farwa, Umme
Khan, Faisal Rashid
Yusra Medical and Dental College ; , Department of Pathology ;

Oman Med. J. 2015; 30 (2): 100-103
Oman Medical Journal
Journal Country: Oman
P-ISSN: 1999-768X
E-ISSN: 2070-5204
Type of Publication: Journal Article
Category: Humans, Male, Female,
Type of Research: Clinical
Keywords: Metabolic Syndrome X
Broad Subjects: Noncommunicable Diseases, Inflammation ,Insulin Resistance ,Adiposity ,Obesity
Citation: Wajiha Farooq ,Umme Farwa ,Faisal Rashid Khan , The metabolic syndrome and inflammation: role of insulin resistance and increased adiposity, Oman Med. J. 2015; 30 (2): 100-103

Abstract English

We sought to determine the role of obesity and insulin resistance [IR] in the pathogenesis of inflammation in metabolic syndrome [MetS] . Our study included 100 patients with MetS and 100 age and gender matched control patients who attended a tertiary care laboratory in Rawalpindi, Pakistan. Anthropometric data was obtained including height and weight to calculate body mass index. A record of patient’s blood pressure [BP] , waist circumference [WC] and hip circumference [HC] was made. Biochemical analysis included measurements of fasting glucose, triglycerides [TG] , high-density lipoprotein cholesterol [HDL-c] , insulin, and high-sensitivity C reactive protein [hsCRP] . IR was determined by the homeostasis mode assessment insulin resistance [HOMA-IR] method. The levels of hs-CRP were found to be elevated in all patients with MetS where it correlated significantly with all its components including measures of obesity, fasting insulin and glucose levels, IR, TG and HDL-c. However, on linear regression analysis only WC, fasting insulin, and HOMA-IR remained significantly correlated with hs-CRP. MetS is a condition characterized by chronic low-grade inflammation, which arises because of increased abdominal adiposity and IR. Large multicenter studies are needed to gain insight into its pathogenesis and derive treatment strategies

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