Despite recent advances in radiation technology, radiotherapy is frequently accompanied by damage to normal tissues as both normal and cancerous tissues have similar response to radiation exposure.
So radioprotectors are of great clinical importance in radiotherapy to decrease the incidence of radiation- induced damage to normal tissues. This study was carried out to assess early and late cytotoxic effects of relatively high single dose of gamma irradiation [7.5 Gy] in adult albino rats and the role of PGE1 analogue, misoprostol as radioprotector against these toxic effects. Seventy adult male albino rats were divided into 5 main groups, group I: negative control, group II: gum acacia, group III: misoprostol, group IIV [a, b] : gamma [gamma] ray irradiated group, Group V [a, b] : misoprostol before gamma irradiation. Serum levels of IL-1 beta, TNF-alpha and flow cytometric analytic study of jejunum and lung cell cycle kinetics was carried out. Histological study of jejunum and lung were also done. Gamma irradiation resulted in significant increase in release of IL-1beta, TNF-alpha and could produce significant alteration of both jejunal and lung cell cycle kinetics, with significant histological and histochemical changes that reflect the early cytotoxic effect of gamma irradiation in the rapid turn-over cells as in the jejunum and the late cytotoxic effect on slow turnover cells as in the lung. In addition misoprostol pretreatment could provide a novel strategy to increase the therapeutic gain in cancer radiotherapy as it was an effective radioprotector that could ameliorate these toxic effects
Zeinab A. Abdel Haleem ,Zeinab A. Abdel Haleem ,Manal M. Zohdy ,
The protective role of synthetic PGE1 analogue against both early and late cytotoxic effects of Gamma irradiation in adult albino rats,
New Egypt. J. Med. 2004;
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