Henan University of Science and Technology ; Nanjing Agricultural University, Animal College of Science and Technology ; Laboratory of Veterinary Pharmacology and Toxicology, Department of Basic Veterinary Medicine ;
The effects of three selective oral inhibitors, fluvoxamine [FLU] , ketoconazole [KET] , and verapamil [VER] , on the pharmacokinetics [PK] of florfenicol [FFC] were investigated in chickens.
The chickens were administered orally with saline solution [SAL] , FLU [60 mg/kg] , KET [25 mg/kg] , or VER [9 mg/kg] for 7 consecutive days. Florfenicol was given to the chickens at a single dose of 30 mg/kg orally. Blood samples were collected from each chicken at 0 to 12 h post-administration of FFC. The plasma concentration of FFC was analyzed by high-performance liquid chromatography [HPLC] . The AUC of FFC increased and the Cl[s] of FFC decreased with oral co-administration of KET in chickens, and the C[max] of FFC increased with VER. While the AUC, the Cl[s] and the C[max] of FFC were all invariable with FLU. These data suggested that CYP 3A played a key role in the PK of FFC in chickens, however, P-glycoprotein [P-gp] and CYP 1A did not. The results imply that the adverse drug-drug interaction may occur in the use of FFC if the co-administrated drugs are the substrates, inducers or inhibitors of CYP 3A or/and P-gp
G. Y. Wang ,G. Y. Wang ,H. H. Zheng ,K. Y. Zhang ,F. Yang ,T. Kong ,B. Zhou ,Sh. X. Jiang ,
The roles of cytochrome P450 and P-glycoprotein in the pharmacokinetics of florfenicol in chickens,
Iran. J. Vet. Res. 2018;
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