Twenty pregnant patients induced hypertension in late pregnancy [30-36 weeks] were randomly allocated to either Nalthrexone [R Trexan] , specific opioid receptor antagonist, or placebo treatment.
Nalthrexone was given in the form of tablets, 50 mg/12 hours. Blood pressure was measured twice daily and measuring of proteinunria was done daily with observation of edema of the lower limbs. The serum levels of prolactin before, one week and 2 weeks after treatment, were measured by radioimmunoassay. This was done also to 51 normal pregnant women in the same gestational age. The results show normalization of blood pressure, subsidence of pretibial edema and minimal decrease in body weight. This was associated with decrease of serum proloctin from 148 +/- 12.8 to 23.4 +/- 4.76 ng/ml after treatment. All babies were delivered at term in a healthy condition. There was no effect on the initiation of lactation which was normal up to 3 months after delivery. The present results of potential value from the clinical and biological points of view are: Nalthrexone is an effective and safe drug to be used in PIH. Beta-endorphin may play a role in the pathogenesis of PIH through controlling the release of prolactin
Hossam T. Salem ,
The use of specific opioid receptor antagonist [nalthrexone]in hypertensive pregnancy,
Assiut Med. J. 1994;
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