Ketoconazole is an oral antifungal drug used to treat systemic and superficial fungal infection. It has several side effects, the blockage of testosterone biosynthesis is one of the most important.
The ultrastructural changes of the seminiferous tubules of testies of rabbits are investigated. Ten adult male normal rabbits were given the drug orally in a dose of 3 mg/kg body weight every day for one month. Five control animals were also used. Testicular specimens were taken, fixed and processed for ultrastructural study. Variable degrees of degenerative changes were seen in the spermatogenic cells, varied from vacuolation of the cytoplasm and degenerated mitochondria to complete destruction of the nucleus
S. A. Arafa ,
Ultrastructural evaluation of the effect of ketoconazole on the seminiferous tubules of rabbits,
Bull. Alex. Fac. Med. 1994;
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