Background and Aim : the usefulness of preoperative Carcinoembryonic antigen [CEA] in colorectal cancer [CRC] remains unsettled as regards its role in management and follow up of CRC patients.
Efficacy of basal CEA in the diagnosis, prognosis, follow up and therapy of CRC patients will be assessed in this study Patients and Methods : 200 CRC patients and 100 persons as a healthy control were included in the study. Basal CEA was done before resection. Postoperative Dukes' staging was adopted. Routine follow up and CEA estimation were done
Results : the mean CEA in CRC patients [17.3 ng% +/- 1.67] was significantly higher than control [3.41 ng% +/- 1.1] . A significant association between mean basal CEA and Dukes' classes was evident [it was 7.8, 12.7, 25.8 ng% for Dukes' A, B, C] . The validity of basal CEA in primary CRC diagnosis was highly positive, with higher efficacy in advanced disease detection and negative exclusion power for DFS prediction. Basal CEA was a discriminant factor in prognosis. DFT and DFS were higher in patients with CEA = 5 ng% Conclusion : the preoperative CEA identifies subsets with favourable, indolent and uneven biological behaviour [= 5, =15, > 15 ng %] . With conventional staging, it forms strong prognostic tool that supplies practice guideline for follow up and therapy
Saleh El Awady ,Waleed Omar ,Sabry A. Mahmoud ,Mohammad El Arman ,Mohamed Farid ,
Utility of preoperative serum carcinoemberyonic antigen in colorectal cancer patients,
Benha Med. J. 2004;
739-759 Views : 0