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Vitamin D and respiratory disorder

Authors

Hushmand Mahnaz
Behmanesh, Fatemeh
Ahanchian, Hamid
Khalesi, Maryam
Ataei, Alireza
Mashhad University of Medical Sciences ; , Ghaem Hospital ; School of Medicine, Departments of Pediatrics ;

Rev. Clin. Med. 2015; 2 (4): 195-199
Reviews in Clinical Medicine [RCM]
Journal Country: Islamic Republic of Iran
P-ISSN: 2345-6256
E-ISSN: 2345-6892
Type of Publication: Review
Category: Humans,
Type of Research: Clinical
Keywords: Vitamin D / analogs & derivatives
Board Subjects: Noncommunicable Diseases, Respiration Disorders ,Vitamin D Deficiency ,Immunomodulation ,Asthma
Citation: Mahnaz Hushmand ,Fatemeh Behmanesh ,Hamid Ahanchian ,Maryam Khalesi ,Alireza Ataei , Vitamin D and respiratory disorder, Rev. Clin. Med. 2015; 2 (4): 195-199

Abstract English

The active form of vitamin D is synthesized in some body organs following sun exposure and dietary intake. Vitamin D exhibits its major and critical effects not only through regulation of calcium and phosphate metabolism but also by influencing on respiratory and immune system. Serum concentrations of 25-hydroxyvitamin D below the optimum limit lead to vitamin D insufficiency or maybe deficiency. These inappropriate concentrations of vitamin D lead to different types of pulmonary diseases such as viral and bacterial respiratory infection, asthma, chronic obstructive pulmonary disease, and cancer. In this review we described the association between vitamin D deficiency and severe therapy resistant asthma. We also reviewed the underlying molecular mechanism of vitamin D deficiency in children with severetherapy resistant asthma. Based on current information, future clinical trial are needed to study the role of vitamin D supplementation on different groups of patients with severe asthma including infants, children of school age, and ethnic minorities

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